Synthetic drugs are reshaping the global drug market. Faster to produce, easier to move, and harder to regulate. This video unpacks the 2025 Global Organized Crime Index findings and expert insights on how fentanyl, methamphetamine, “kush,” and other synthetics are proliferating worldwide. From overdoses in North America’s to West Africa’s state-of-emergency responses, we explore why traditional, geography-based drug policies no longer fit today’s reality; and what cross-sector, cross-border solutions could work.